Reports from France show that at least 42 people have been killed in a crash in the south-west of the country.
The two vehicles are reported to have collided head-on near Libourne, in the Gironde region, east of Bordeaux.
A fire official told the Agence France Presse that the dead were mostly adult passengers on the bus. The lorry driver was also killed.
France's president said he had been "plunged into sadness by the tragedy". Prime Minister Manuel Valls is at the scene.